Synthetic Route of 4928-87-4, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, molecular formula is C3H3N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
A solution of intermediate 42 (0.288, 0.58 mmol) was dissolved in 50 mmol of HOBT(: 1 (0.178, 0.89 mmol)EDCl(0.118, 0.83 mmol)After stirring, lH-1,2,4-triazole-3-carboxylic acid (0.078, 0.62 mmol) was added at room temperatureStirring 12h, TLC detection, the end of the reaction, the liquid spin the crude product, the crude product by silica gel G column chromatography [eluent (methanol: dichloromethaneHexane: aqueous ammonia = 50: 500: 1 (nu: nu: nu)] to give 0.23 g of the title compound of Example 30-a, yield 36%
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 1,2,4-Triazole-3-carboxylic acid, hurry up and to see.
Reference:
Patent; Beijing Foreland Pharma Co., Ltd; Zhang, Xingmin; Wang, Ensi; Niu, Shengxiu; Guo, Jing; Dai, Zhuolin; Zheng, Nan; Ji, Qi; Li, Qinyan; Liang, Tie; (109 pag.)CN104411706; (2016); B;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics