Synthetic Route of 143426-50-0, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 143426-50-0, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of (4-(1 H-1 ,2,4-triazol-1-yl)phenyl)methanol (133 mg, 0.76 mmol) in dry DCM (2 mL), SOCI2 (0.1 mL, 1.52 mol) was added at 0 C and the resulting mixture was stirred for 3 h at RT. The completion of the reaction was monitored by TLC. The reaction mixture was concentrated under vacuum and the resulting product was co-distilled with DCM (2 x 10 mL) to get the title compound that was used without any further purification. Yield: 60% (1 10 mg, pale yellow solid). 1H NMR (400 MHz, DMSO -cfe): d 9.33 (s, 1 H), 8.26 (s, 1 H), 7.89 (d, 8.8 Hz, 2H), 7.64 (d, J = 8.8 Hz, 2H), 4.85 (s, 2H). LCMS: (Method A) 194.1 (M+H), Rt.1.73 min, 79.10% (Max).
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Reference:
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; WISHART, Grant; KULKARNI, Santosh S.; RAKESH, Paul; (338 pag.)WO2020/39027; (2020); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics