Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 1H-[1,2,3]Triazole-4-carboxylic acid
To a solution of (E)-1-(4-(2-aminoethyl)piperidin-1-yl)-3-(4-chloro-2-((5-methyl-2H-tetrazol-2- yl)methyl)phenyl)prop-2-en-1-one (Example 145, step 2)(53 mg, 0.136 mmol), DIPEA (0.095ml, 0.545 mmol) and 1H-1,2,3-triazole-4-carboxylic acid (17 mg, 0.150 mmol) in DMF (2 ml)was added T3P, 50% solution in EtOAc (0.159 ml, 0.273 mmol). The resultant mixture was stirred at room temperature for 5 hours. Water (0.5 ml) was added and the mixture wasconcentrated in vacuo. The residue was purified by reverse phase preparative HPLC to afford the the title compound.LC-MS: Rt 1.01 mins; [M+H]+ 484.6 Method 2minLowpHvol
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 16681-70-2.
Reference:
Patent; NOVARTIS AG; BEATTIE, David; BAETTIG, Urs; LEGRAND, Darren Mark; LISTER, Andrew Stuart; MCKENNA, Jeffrey; PEARCE, David William; SANDHAM, David Andrew; STEWARD, Oliver Ross; THOMSON, Christopher; WO2015/8230; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics