Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C3H3N3O2
lH-l,2,3-triazole-4-carboxylic acid (9.8 mg, 87 muiotaetaomicron) and HATU (36.4 mg, 96 muiotaetaomicron) were combined in DMF (3.0 mL) and stirred at room temperature for 15 minutes. Compound 2 (40.3 mg, 87 muiotaetaomicron) and DIPEA (46 mu,, 261 muiotaetaomicron) were added and the resulting solution was stirred at room temperature for 15 minutes, after which time LCMS indicated desired product formation. The solvent was removed in vacuo and the crude residue was purified by reverse phase chromatography to yield Compound c (34.5 mg) as a TFA salt. MS m/z [M+H]+ calc’d for C28H3 found 558.
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 16681-70-2
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; FLEURY, Melissa; BEAUSOLIEL, Anne-Marie; HUGHES, Adam D.; LONG, Daniel D.; WILTON, Donna A.A.; WO2015/116786; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics