Related Products of 7411-23-6, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3,5-Dibromo-1,2,4-triazole (1; 658 mg, 2.9 mmol) and salicylic alcohol2c (447 mg, 2.9 mmol) were refluxed for 2 h in DMF (10 mL). Aftercompletion of the reaction, the mixture was cooled and poured intoH2O (30 mL). The precipitate formed was collected by filtration,washed with H2O, dried, and recrystallized from EtOH; yield: 585 mg(60%); colorless crystals; mp 149-150 C.IR (KBr): 3500-3000 (O-H), 1612, 1593, 1553, 1520, 1485, 1468,1433, 1364, 1290, 1267, 1231, 1184, 1069, 1005, 916, 837, 777, 760,721, 704 cm-1.1H NMR (400 MHz, DMSO-d6): delta = 9.09 (s, 1 H, OH), 6.91 (dd, J = 8.2,1.2 Hz, 1 H, Ar), 6.73 (t, J = 7.9 Hz, 1 H, Ar), 6.57 (d, J = 7.6 Hz, 1 H, Ar),5.26 (s, 2 H, CH2), 3.75 (s, 6 H, 2 × CH3O).1H NMR (400 MHz, CD3CN): delta = 6.91 (dd, J = 8.0, 1.4 Hz, 1 H, Ar), 6.89(br s, 1 H, OH), 6.79 (t, J = 8.0 Hz, 1 H, Ar), 6.66 (dd, J = 7.8, 1.4 Hz, 1 H,Ar), 5.27 (s, 2 H, CH2), 3.82 (s, 6 H, 2 × CH3O).13C NMR (100 MHz, DMSO-d6): delta = 148.0 (C), 144.8 (C), 139.6 (C),131.7 (C), 121.5 (C, CH), 119.5 (CH), 112.4 (CH), 56.4 (2 × CH3), 49.2(CH2).13C NMR (100 MHz, CD3CN): delta = 147.2 (C), 144.2 (C), 139.4 (C), 130.5(C), 121.4 (CH), 120.3 (C), 119.7 (CH), 111.7 (CH), 55.9 (2 × CH3), 48.7(CH2).Anal. Calcd for C10H9Br2N3O2: C, 33.09; H, 2.50; N, 11.58. Found: C,32.95; H, 2.41; N, 11.45.
Future efforts will undeniably focus on the diversification of the new catalytic transformations. These may comprise an expansion of the substrate scope from aromatic and heteroaromatic compounds to other hydrocarbons. Keep reading other articles of 7411-23-6.
Reference:
Article; Osipov, Dmitry V.; Osyanin, Vitaly A.; Voskressensky, Leonid G.; Klimochkin, Yuri N.; Synthesis; vol. 49; 10; (2017); p. 2286 – 2296;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics