Electric Literature of 7343-34-2, New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 7343-34-2, name is 3,5-Dimethyl-4H-1,2,4-triazole, molecular formula is C4H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
5-cWoro-3-(3,5-dimethyl-lH-l,2,4-triazol-l-yl)pyridazine (23-2): To a stirring solution of 3,5-dichloropyridazine (23-1, 5.00 g , 33.5 mmol, 1.0 eq.) in tetrahydrofuran (125 ml) at 0 °C was added cesium carbonate (17.7 g, 50.3 mmol, 1.5 eq.), followed by 3,5-dimethyl-lH-l,2,4~triazole (3.25 g, 33.5 mmol, 1.0 eq.) in tetrahydrofuran (125 mL) dropwise. The resulting reaction mixture was stirred for 1 hour at the same temperature and then warmed to room temperature and stirred for another 3 hours, then heated to 60 °C and stirred for 6 hours. The solvent was removed under reduced pressure and the residue was diluted with water (200 mL) and extracted with DCM (3 chi 80 mL). The combined organic layers were dried over Na2S04, filtered and concentrated. The residue was purified by silica gel column chromatography (70percent ethyl acetate in hexanes) to afford 5-chloro-3-(3,5-dimethyl-lH-l,2,4-triazol-l-yl)pyridazine (23-2) as a white solid. 1H NMR (300 MHz, CDC13) delta 9.11 (d, 1H, J= 2.1 Hz), 8.20 (d, 1H, J= 2.1 Hz), 2.96 (s, 3H), 2.43 (s, 3H).
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 3,5-Dimethyl-4H-1,2,4-triazole, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COX, Christopher, D.; DUDKIN, Vadim, Y.; KIM, June, J.; KUDUK, Scott, D.; MCVEAN, Carol; REGER, Thomas; STEEN, Justin; STEELE, Thomas; WO2013/52526; (2013); A1;,
1,2,3-Triazole – Wikipedia,
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