New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3641-13-2
3-Amino-1,2,4-triazole-5-carboxylic acid hydrate (1.28g, O.OImol) was dissolved in water (50ml). Sodium nitrite (0.76g, 0.011mol) was added and the solution was stirred until the sodium nitrite had dissolved. The mixture was then added dropwise to a cooled mix of ice-water (30g) and concentrated hydrochloric acid (3.0ml) at 0-5C. The mixture was stirred for 30 minutes at 0-5C and then excess nitrous acid was destroyed by the addition of sulfamic acid. The resultant diazonium salt suspension was added slowly to a solution of 6-hydroxyquinoline (1.45g, O.OImol) in water (100ml) at pH 8-9 (adjusted with 2M NaOH) and cooled to below 5C. The reaction mixture was then stirred at 0-5C for one hour and the product was precipitated by acidification to pH 4 with 2M HCI and collected by filtration. The product was washed with water and then dried in a vacuumdesiccator to give an orange solid.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 5-Amino-4H-1,2,4-triazole-3-carboxylic acid ,and how the biochemistry of the body works.
Reference:
Patent; AVECIA LIMITED; WO2004/108834; (2004); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics