Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 288-36-8, name is 1H-1,2,3-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1H-1,2,3-Triazole
To a mixture of 2-bromo-4-fluorobenzoic acid (30 g, 137 mmol), cesium carbonate (89.26 g, 274 mmol), and copper(I) iodide (5.27 g, 27.4 mmol) in DMF (200 mL) were added N,N? -dimethylcyclohexane- 1 ,2-diamine (3.7 mL,23 .3 mmol) and 1H- 1,2,3 -triazole (18.92 g, 274 mmol). The resulting mixture was stirred at 110 C overnight, cooled, concentrated in vacuo, and diluted with water (150 mL). The aqueous layer was extracted withEtOAc (300 mL x 3). The aqueous layer was acidified with 2 N HC1 and extracted with EtOAc(300 ml. x 4). The combined organic layers were washed with brine (150 mL x 3), dried overNa2SO4, filtered, and concentrated in vacuo. The residue was purified by silica gel columnchromatography gel (petroleum ether: EtOAc = 100: 1 5 : 1) to provide the title compound asa solid. LRMS m/z (M+H) 208.0 found, 208.0 required.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1H-1,2,3-Triazole, in my other articles.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; REGER, Thomas, S.; SKUDLAREK, Jason, W.; (50 pag.)WO2016/100162; (2016); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics