New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 288-88-0, name is 1H-1,2,4-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 288-88-0
To a 500 ml three-necked flask, 21.0 g of 1,2,4-triazole was added.And adding 150.0 g of diethylene glycol monomethyl ether and 7.0 g of potassium hydroxide,Heating in an oil bath, controlling the internal temperature at 100-110 C;then,60.0 g of the reaction starting material A was slowly added dropwise, and the dropping time was 1 h.After the completion of the dropwise addition, the mixture was stirred at 100 to 120 C for 10 hours, and the reaction of the starting material A was monitored by TLC.Then, the reaction solution was allowed to stand to cool to room temperature, incubated in an ice water bath for 1 h, suction filtration, and the filtered mother liquor was collected and applied, and the filter cake was taken.Rinse with 50 ml of a mixed solvent of n-hexane and petroleum ether.Drying in vacuo, the product quality of tebuconazole is 68.6g.The purity was 98.2%, and the total yield was 92.1%.The tebuconazole product characterization data is the same as in Example 1.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1H-1,2,4-Triazole, in my other articles.
Reference:
Patent; Shanghai Sheng Nong Biochemical Goods Co., Ltd.; Ye Zhenjun; Wang Tao; Xu Haiyan; Bi Qiang; Han Haiping; (6 pag.)CN109705048; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics