New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 6523-49-5
To a solution of formamidine from Step 3 (250mg, 0.73mM) in acetic acid (2ml) was added the 4-triazolylaniline (117mg, 0.73mM). The reaction was heated to 125C for2hrs. The mixture was cooled down and 15ml of 2N NaOH was added. The product crashed out and was isolated by filtration. The solid was purified by column (SiOH) with DCM:EtOH:NH3 400-200:8:1 and isolated as a yellow solid (258mg, 75%).1H NMR (D6-DMSO) delta 10.06 (IH , broad s), 9.29 (IH, s), 8.81 (IH, s) 8.63 (IH, s), 8.25 (2H, m), 8.09 (IH, s), 8.05 (IH, s), 7.83 (4H, m), 7.70 (IH, d, J 10Hz), 7.39 (IH, t,J 10Hz), 4.21 (2H, t, J 7.5Hz), 2.68 (2H, t, J 7.5Hz), 2.24 (6H , s).LC-MS rt 1.99 m/z 470 ES+
If you are hungry for even more, make sure to check my other article about 6523-49-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics