6-(Substituted methylene)penems, potent broad-spectrum inhibitors of bacterial β-lactamase. V. Chiral 1,2,3-triazolyl derivatives was written by Bennett, Isabel S.;Brooks, Gerald;Broom, Nigel J. P.;Calvert, Stephen H.;Coleman, Kenneth;Francois, Irene. And the article was included in Journal of Antibiotics in 1991.SDS of cas: 40594-98-7 This article mentions the following:
A series of (5R)-6-triazolylmethylenepenems I [R = H, Me, Et, Pr, CF3CH2, NaO2CCH2, Me2N, MeO, HO, HOCH2CH2, HO(CH2)3, cyclopropyl] with potent β-lactamase inhibitory activity were prepared and their structure-activity relationships determined In most cases, their in vitro synergistic activity with amoxycillin is superior to that of clavulanic acid, sulbactam and tazobactam. Against an Escherichia coli TEM-1 infection in mice, I showed a broad range of potencies; an optimum polarity was found, however, which gave maximum potency. In the experiment, the researchers used many compounds, for example, Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7SDS of cas: 40594-98-7).
Ethyl 1H-1,2,3-triazole-5-carboxylate (cas: 40594-98-7) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Both the triazoles and their derivatives have significant biological properties including antimicrobial, antiviral, antitubercular, anticancer, anticonvulsant, analgesic, antioxidant, anti-inflammatory, and antidepressant activities.SDS of cas: 40594-98-7
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics