7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 7411-23-6
3,5-Dibromo-1,2,4-triazole (1; 658 mg, 2.9 mmol) and Mannich base2p (752 mg, 2.9 mmol) were refluxed for 2 h in EtOH (10 mL). Productwas isolated analogously to compound 4a; yield: 475 mg (59%); colorlesscrystals; mp 199-200 C (EtOH).IR (KBr): 3309, 3240, 1643, 1582, 1539, 1512, 1454, 1427, 1369, 1346,1300, 1261, 1204, 1084, 1045, 930, 810, 775 cm-1.1H NMR (400 MHz, DMSO-d6): delta = 11.46 (s, 1 H, NH), 9.21 (s, 1 H, OH),7.52 (s, 1 , NHCO), 7.22 (d, J = 8.7 Hz, 1 H, Ar), 6.78 (d, J = 8.7 Hz, 1 H,Ar), 5.48 (s, 2 H, CH2N), 3.45 (td, J = 6.9, 2.3 Hz, 2 H, CH2), 3.01 (t, J =6.9 Hz, 2 H, CH2).13C NMR (100 MHz, DMSO-d6): delta = 162.3 (C=O), 150.4 (C), 139.4 (C),132.5 (C), 131.3 (C), 128.8 (C), 125.7 (C), 117.1 (C), 115.0 (CH), 114.5(CH), 110.3 (C), 46.0 (CH2), 41.5 (CH2), 22.8 (CH2).Anal. Calcd for C14H11Br2N5O2: C, 38.12; H, 2.51; N, 15.88. Found: C,38.05; H, 2.46; N, 15.92.
Statistics shows that 7411-23-6 is playing an increasingly important role. we look forward to future research findings about 3,5-Dibromo-1H-1,2,4-triazole.
Reference:
Article; Osipov, Dmitry V.; Osyanin, Vitaly A.; Voskressensky, Leonid G.; Klimochkin, Yuri N.; Synthesis; vol. 49; 10; (2017); p. 2286 – 2296;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics