As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7170-01-6 name is 3-Methyl-1H-1,2,4-triazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 7170-01-6
Step A. 2-Chloro-4-(3 -methyl-i H-i ,2,4-triazol- 1 -yl)benzaldehydeTo a solution of 2-chloro-4-fluorobenzaldehyde (95 mmol, 15 g) and 3-methyl-1H-i,2,4-triazole(114 mmol, 9.4 g) in CH3CN (300 mL) was added K2C03 (142 mmol, 20 g) and stirred at 60 C.After 24 h, the reaction mixture was added water and extracted with EtOAc. The organic extracts washed with saturated aq. NaC1, dried over Na2SO4, and filtered and concentrated in vacuo. The crude was purified by column chromatography (heptane :EtOAc = 20:80-10:90) to give the title compound. MS (ESI) mlz = 222, 224 (M+H)?H NMR (300 MHz, CDC13) 5 (ppm): 10.45 (1H, s), 8.55 (1H, s), 8.06 (1H, d, J 8.6 Hz), 7.87(1H, d, J= 2.1 Hz), 7.68 (1H, dd, J 8.6, 2.1 Hz), 2.51 (3H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Methyl-1H-1,2,4-triazole, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MOCHIDA PHARMACEUTICAL CO., LTD.; SAKURADA, Isao; HIRABAYASHI, Tomokazu; MAEDA, Yoshitaka; NAGASUE, Hiroshi; MIZUNO, Takashi; XU, Jiayi; ZHANG, Ting; SMITH, Cameron; PARKER, Dann; WO2015/160636; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics