4922-98-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a stirred solution of the appropriate 1,2,4-triazole 8a-t (1 mmol)in dry pyridine (5 mL) cooled at ?5 ¡ãC was added 3?,4?,5?-trimethoxybenzoylchloride (252 mg, 1.1 mol, 1.1 equiv.) in small portions. For the preparation of compounds 5u and 5v, 3?,4?-dimethoxybenzoylchloride (221 mg, 1.1 mmol, 1.1 equiv.) or 4?-methoxybenzoyl chloride(188 mg, 1.1 mmol, 1.1 equiv.), respectively, were added to derivative 5k. The reaction mixture was kept for 30 min at ?5 ¡ãC and then overnight at room temperature. Pyridine was removed by evaporation under reduced pressure. To the residue was added CH2Cl2, and the organic phase was washed with saturated aq. NaHCO3, water and brine and dried. The reaction mixture was filtered, and the solvent was removed in vacuo. The crude residue was suspended in ethyl ether(15 mL), the resulting suspension stirred for 30 min, filtered and the residue filtered under reduced pressure to furnish the 1-aroyl-3-aryl-5-amino-1H-1,2,4-triazole derivatives 5a-v. Compounds 5a, 5e, 5f and 5hwere characterized by spectroscopic and analytical data, and our datawere in agreement with those previously reported [30]. 5.1.4.1. (5-Amino-3-phenyl-1H-1,2,4-triazol-1-yl) (3,4,5-trimethoxyphenyl)methanone (5a). Synthesized according to method C, derivative 5a wasobtained as a white solid (yield 66percent); mp 225?227 ¡ãC. 1HNMR(d6-DMSO)delta: 3.80 (s, 3H), 3.87 (s, 6H), 7.47 (m, 3H), 7.68 (s, 2H), 7.86 (bs, 2H), 8.03(m, 2H). 13C NMR (d6-DMSO) delta: 55.96 (2C), 60.13, 108.92 (2C), 126.22(2C), 126.42, 128.70 (2C), 130.02, 130.64, 141.60, 152.00 (2C), 159.05,159.40, 166.39. MS (ESI): [M+1]+=355.37. Anal. calcd forC18H18N4O4. C, 61.01; H, 5.12; N, 15.81; found: C, 60.78; H, 5.01; N,15.67.
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Reference:
Article; Romagnoli, Romeo; Prencipe, Filippo; Oliva, Paola; Baraldi, Stefania; Baraldi, Pier Giovanni; Brancale, Andrea; Ferla, Salvatore; Hamel, Ernest; Bortolozzi, Roberta; Viola, Giampietro; Bioorganic Chemistry; vol. 80; (2018); p. 361 – 374;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics