Adding a certain compound to certain chemical reactions, such as: 27808-16-8, name is 4-Methyl-1H-1,2,3-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 27808-16-8, SDS of cas: 27808-16-8
A mixture of 33(430 mg, 1.00 mmol), 4-methyl-1H-1,2,3-triazole (100 mg,1.20 mmol) and K2CO3 (208 mg, 1.50 mmol) in DMF (4 mL)was stirred at 80C for 2 h. The mixture was quenched withwater at r.t. and extracted with EtOAc. The organic layer wasseparated, washed with water and saturated aqueous NaCl,dried over anhydrous MgSO4 and concentrated in vacuo(508.7 mg). The residue was purified by using preparativeHPLC (column: L-Column2 ODS 20 mm ID¡Á150 mm L;mobile phase A: 0.1% TFA in water; mobile phase B: 0.1%TFA in acetonitrile; flow rate: 20 mL/min). The first elutingfactions (tR1) were concentrated to dryness, and washed withsaturated aqueous NaHCO3, extracted with EtOAc. The organic layer was separated, washed with water and saturatedaqueous NaCl, dried over anhydrous MgSO4 and concentratedin vacuo. The residue (42.7 mg) was crystallized from hexane-ethyl acetate to give 17 (34.4 mg, 0.072 mmol, 7.2%) asa white solid. 1H-NMR (300 MHz, DMSO-d6) delta: 1.04 (3H, s),1.37 (3H, s), 2.44 (3H, s), 4.87 (1H, d, J=8.3 Hz), 5.39 (1H, s),7.23-7.34 (2H, m), 7.48-7.58 (2H, m), 7.93 (1H, d, J=7.5 Hz),8.55 (1H, s), 8.88 (1H, d, J=0.8 Hz), 9.07 (1H, d, J=8.3 Hz),9.50 (1H, d, J=7.5 Hz). MS (ESI/APCI) m/z 476.2 [M+H]+.HPLC purity: 99.4%. mp 260C.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Mikami, Satoshi; Kawasaki, Masanori; Ikeda, Shuhei; Negoro, Nobuyuki; Nakamura, Shinji; Nomura, Izumi; Ashizawa, Tomoko; Kokubo, Hironori; Hoffman, Isaac Dylan; Zou, Hua; Oki, Hideyuki; Uchiyama, Noriko; Hiura, Yuuto; Miyamoto, Maki; Itou, Yuuki; Nakashima, Masato; Iwashita, Hiroki; Taniguchi, Takahiko; Chemical and Pharmaceutical Bulletin; vol. 65; 11; (2017); p. 1058 – 1077;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics