Adding a certain compound to certain chemical reactions, such as: 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16681-70-2, HPLC of Formula: C3H3N3O2
1 .92 g (50 % purity, 3.00 mmol) 8-{[2-(trifluoromethyl)phenyl]sulfonyl}-3,8- diazabicyclo[3.2.1 ]octane (Intermediate 3) were reacted in analogy to example 1 , procedure 1 .2 with 0.678 g (6 mmol, 2 eq) 1 H-1 ,2,3-triazole-5-carboxylic acid to yield after work-up and purification 792 mg (62%) of the title compound 1 H-1 ,2,3-triazol-4- yl[(8-{[2-(trifluoromethyl)phenyl]sulfonyl}-3,8-diazabicyclo[3.2.1 ]oct-3-yl]methanone. (0504) LC-MS (Method 1 ): Rt = 0.96 min; MS (ESIpos): m/z = 416 [M+H]+ (0505) 1 H-NMR (400 MHz, DMSO-d6) delta [ppm]: 1 .602 (2.82), 1 .629 (2.52), 1 .689 (12.16), 1 .980 (0.53), 2.073 (1 .54), 2.327 (1 .17), 2.669 (1.20), 2.673 (0.87), 2.934 (3.84), 2.964 (4.10), 3.379 (5.16), 4.293 (5.08), 4.355 (9.64), 4.386 (4.07), 4.519 (0.72), 7.890 (1 .47), 7.908 (5.87), 7.913 (7.23), 7.920 (16.00), 7.927 (6.81 ), 7.932 (7.53), 7.936 (7.64), 7.950 (2.37), 7.955 (1 .54), 8.018 (0.79), 8.030 (7.57), 8.037 (6.89), 8.053 (5.61 ), 8.295 (7.27), 8.31 1 (6.51 ), 8.317 (6.21 ), 15.524 (0.53).
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Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; SIEBENEICHER, Holger; STEUBER, Holger; TER LAAK, Antonius; NUBBEMEYER, Reinhard; ROTTMANN, Antje; IRLBACHER, Horst; BADER, Benjamin; PETERS, Michaele; WAGENFELD, Andrea; TEREBESI, Ildiko; (123 pag.)WO2017/202817; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics