Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, A new synthetic method of this compound is introduced below., COA of Formula: C9H7N3O2
Step (vii): tert-butyl N-{4-[(4-methoxyphenyl)methoxy]-2-[2-(2H-l,2,3-triazol-2- yl)benzamido]cyclopentyl}carbamate To a solution of ieri-butyl N-{2-amino-4-[(4- methoxyphenyl)methoxy]cyclopentyl}carbamate (1.71 g, 5.08 mmol) in dry DMF (17 ml) was added 2-(2H-l,2,3-triazol-2-yl)benzoic acid (CAS number 1001401 -62-2; 1.058 g, 5.59 mmol), HATU (2.90 g, 7.62 mmol) and triethylamine (2.125 ml, 15.25 mmol). The reaction was stirred at room temperature for 72 hours. The reaction was partitioned between ethyl acetate and water, washed with brine, dried over magnesium sulfate, concentrated in vacuo and purified by column chromatography (silica, 0-100% ethyl acetate / petrol) to afford the title compound. 1H NMR (400 MHz, DMSO-d6) delta ppm 1.37 (s, 9 H), 1.46 – 1.59 (m, 1 H), 1.58 – 1.77 (m, 1 H), 1.86 – 1.97 (m, 1 H), 2.18 – 2.37 (m, 1 H), 3.67 – 3.79 (m, 4 H), 3.83 – 4.01 (m, 2 H), 4.32 (s, 2 H), 6.85 – 6.95 (m, 2 H), 7.17 – 7.31 (m, 2 H), 7.44 – 7.54 (m, 2 H), 7.55 – 7.66 (m, 1 H), 7.76 (s, 1 H), 7.96 – 8.05 (m, 2 H)MS ES+: 508
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics