Electric Literature of 135242-93-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 135242-93-2 as follows.
To a mixture of (l-methyl-l/-/-l,2,4-triazol-3-yl)methanol (400 mg, 3.54 mmol) and iodobenzene diacetate (1.25 g, 3.89 mmol) in dichloromethane (10 mL) was added TEMPO ((2, 2,6,6- tetramethylpiperidin-l-yl)oxyl) (56 mg, 354 pmol). The mixture was stirred at 15-20C for 2h. The mixture was concentrated in vacuo. The residue was purified by silica gel chromatography (petroleum ethenethyl acetate = 1:2) to give l-methyl-l/-/-l,2,4-triazole-3-carbaldehyde (300 mg, 2.70 mmol, 76% yield). XH NMR (chloroform-d 400 MHz) d 10.01 (s, 1H), 8.19 (s, 1H), 4.06 (s, 3H).
According to the analysis of related databases, 135242-93-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; JUHL, Karsten; MARIGO, Mauro; VITAL, Paulo, Jorge, Vieira; JESSING, Mikkel; LANGGARD, Morten; RASMUSSEN, Lars, Kyhn; CLEMENTSON, Carl, Martin, Sebastian; (275 pag.)WO2019/115566; (2019); A1;,
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