Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4923-01-7, name is 5-Methyl-4H-1,2,4-triazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C3H6N4
(a) Ethyl 3-oxo-3-(pyridin-2-yl)propanoate (400mg, 2.07mmol) was taken in AcOH (10mL) in a 50mL round bottom flask under N2. To it was added 5-methyl-4H-1,2,4-triazol-3-amine (334mg, 2.49mmol). The reaction mixture was heated at 115C for 12h. The reaction mixture was then evaporated to dryness using toluene as an azeotropic solvent and triturated with diethyl ether. This was finally dried under high vaccum which affored 66a as a brown solid (350mg, 75%). This was then used in the next step without any further purification. LCMS(ESI) m/z 226.03 [M-H+]; 56% (purity).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4923-01-7.
Reference:
Article; Zuniga, Edison S.; Korkegian, Aaron; Mullen, Steven; Hembre, Erik J.; Ornstein, Paul L.; Cortez, Guillermo; Biswas, Kallolmay; Kumar, Naresh; Cramer, Jeffrey; Masquelin, Thierry; Hipskind, Philip A.; Odingo, Joshua; Parish, Tanya; Bioorganic and Medicinal Chemistry; vol. 25; 15; (2017); p. 3922 – 3946;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics