In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40253-47-2 as follows. Recommanded Product: Ethyl 5-methyl-1H-1,2,4-triazole-3-carboxylate
A mixture of ethyl 5-methyl-lH-l ,2,4-triazole-3-carboxylate (1.0 g, 6.45 mmol) and sodium hydroxide (1.702 mL, 32.2 mmol) in tetrahydrofuran (30 mL) was stirred at ambient temperature for 16 hours. Volatiles were removed, and the residue was acidified with 1 N HQ solution. Water was removed under high vacuum, and the crude residue was purified by HPLC (0-70% acetonitrile in 0.1 % trifluoroacetic acid/water on Phenomenex C18 10 mupiiota (250 mm x 50 mm) column at a flowrate of 50 mL/minute) to give 460 mg of the title compound as a white solid.
According to the analysis of related databases, 40253-47-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; FROST, Jennifer, M.; PLIUSHCHEV, Marina, A.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; SWEIS, Ramzi, Farah; DART, Michael, J.; RANDOLPH, John, T.; MURAUSKI, Kathleen; (674 pag.)WO2019/90076; (2019); A1;,
1,2,3-Triazole – Wikipedia,
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