Electric Literature of 6818-99-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6818-99-1 as follows.
Step 1: Synthesis of Compounds of the Formula (IV) 6′-(3-Chloro-1,2,4-triazol-1-yl)-[1(2H), 3′-bipyridin]-2-one (IV-29) 250.0 mg (1.21 mmol) of 6′-chloro-[1(2H),3′-bipyridin]-2-one (IV-14) were stirred in 10 ml of N,N-dimethylformamide (DMF), 438.3 mg (4.23 mmol) of 3-chloro-1,2,4-triazole, 496.0 mg (3.58 mmol) of potassium carbonate, 29.9 mg (0.15 mmol) of copper(I) iodide and 65.4 mg (0.46 mmol) of N,N-dimethylcyclohexane-1,2-diamine were added and the mixture was stirred at 110 C. for 2 days. After cooling, the reaction mixture was extracted with saturated sodium chloride solution and ethyl acetate. For work-up, the organic phase was dried and concentrated under reduced pressure and the residue that remained was purified by column chromatography on silica gel (mobile phase: cyclohexane acetone gradient). This gave 38 mg (100.0% pure, 11.4% yield) of 6′-(3-chloro-1,2,4-triazol-1-yl)-[1(2H),3′-bipyridin]-2-one. Log P value (HCOOH)=1.23 LC-MS (ESI positive)=274.0 (M+) C12H8ClN5O (273.7 g/mol) 1H-NMR (400.0 MHz, DMSO-d6): delta=6.40; 6.55; 7.57; 7.79; 7.97; 8.22 (m, 6H, hetaryl-H); 8.67 (d, 1H, hetaryl-H); 9.51 (s, 1H, hetaryl-H) ppm.
According to the analysis of related databases, 6818-99-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Bayer CropScience Aktiengesellschaft; JESCHKE, Peter; GUTBROD, Oliver; FISCHER, Reiner; HELLWEGE, Elke; LOESEL, Peter; MALSAM, Olga; EILMUS, Sascha; ILG, Kerstin; PORTZ, Daniela; GOERGENS, Ulrich; LISHCHYNSKYI, Anton; (69 pag.)US2018/201600; (2018); A1;,
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