Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13273-53-5, name is 4-Bromo-1-methyl-1H-1,2,3-triazole, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C3H4BrN3
Step 2. (S)-2-(l-(cyclopropanecarbonyl)-2-methyl-6-(l-methyl-lH-l,2,3-triazol-4-yl)-l,2,3,4- tetrahydroquinolin-5-yloxy)benzonitrile [0440] A mixture of (S)-2-(l-(cyclopropanecarbonyl)-2-methyl-6-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)-l,2,3,4-tetrahydroquinolin-5-yloxy)benzonitrile (0.050 g, 0.1 1 mmol), 4-bromo- 1 -methyl- lH-l ,2,3-triazole (0.025 g, 0.15 mmol), cesium carbonate (0.110 g, 0.34 mmol), [Iota, – bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane adduct (0.10 g, 0.01 mmol) in l ,4-dioxane(10 mL) and water (3 mL) was stirred overnight at 80 C. The reaction mixture was cooled to room temperature and filtered through a short pad of Celite. The filtrate was concentrated and purified via preparative thin layer chromatography (eluting with 25% ethyl acetate-petroleum ether) to afford (S)-2-(l-(cyclopropanecarbonyl)-2-methyl-6-(l-methyl-lH-l ,2,3-triazol-4-yl)- l,2,3,4-tetrahydroquinolin-5-yloxy)benzonitrile (0.006 g, 13%) as a white solid. MS (ESI, pos. ion) m/z 414[M+H]+. 1H NMR(400 MHz, CD3OD) delta ppm 0.75-0.82(m, 1H), 0.88-1.05(m, 2H), 1.15- 1.25(m, 3H), 1.28-1.35(m, 1H), 1.45-1.55(m, 1H), 1.97-2.05(m, 1H), 2.15-2.25(m, 1H), 2.27- 2.45(m, 1H), 2.60-2.75(m, 1H), 4.09(s, 3H), 4.75-4.85(m, 1H), 6.58(d, J=8.40 Hz, 1H), 7.17(t, J=8.00 Hz, 1H), 7.45-7.51(m, 1H), 7.57(d, J=8.40 Hz, 1H), 7.78(d, J=1.20 Hz, 1H), 8.03-8.07(m, 2H). MS (ESI, pos. ion) m/z 414[M+H]+.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 13273-53-5.
Reference:
Patent; BAIR, Kenneth W.; HERBERTZ, Torsten; KAUFFMAN, Goss Stryker; KAYSER-BRICKER, Katherine J.; LUKE, George P.; MARTIN, Matthew W.; MILLAN, David S.; SCHILLER, Shawn E. R.; TALBOT, Adam C.; WO2015/74064; (2015); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics