Application of 4928-87-4, These common heterocyclic compound, 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 5-((lR,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)- 8H-pyrazolo[l,5-a]pyrrolo[3,2-e]pyrimidine (0.19 mmol), lH-l,2,4-triazole-3-carboxylic acid (21.7mg, 0.19 mmol), EDC (58.6 mg, OJ lmmol), HOBt (25.9 mg, 0.19 mmol) and DIEA (200 uL, 1.15 mmol) in DMF (5 mL) was stirred at room temperature for 2 h. Purification with prep-LC provided ((lR,3s,5S)-3-(3-(6-phenylpyridin-3-yl)-8H-pyrazolo[l,5- a]pyrrolo[3,2-e]pyrimidin-5-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-l,2,4-triazol-3- yl)mefhanone.
The synthetic route of 4928-87-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MENG, Zhaoyang; PATEL, Mehul, F.; SIDDIQUI, M. Arshad; REDDY, Panduranga Adulla, P.; NAN, Yang; WO2013/16164; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics