Related Products of 138624-97-2, The chemical industry reduces the impact on the environment during synthesis 138624-97-2, name is 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.
A mixture of (3S)-3-amino- 1 ,7-dimethyl-4,5-dihydro-3H-pyrido [4,3-b] azepine-2,8- dione (15 mg, 0.07 mmol), i-hydroxybenzotriazole (ii mg, 0.08 mmol), i-(3-dimethylaminopropyl)-3-ethylcarbodiimidehydrochloride (16 mg, 0.08 mmol) and 1 -benzyli,2,4-triazole-3-carboxylic acid (17 mg, 0.08 mmol) in N,N-dimethylformamide (3 mL) was stirred at 25 C for 2 h. The solvent was removed under reduced pressure. The residue was purified by HPLC reverse phase chromatography (acetonitrile 17-47% / 0.05% NH4OH in water) to afford arbitrarily assigned 1 -benzyl-N- [(3S)- 1 ,7-dimethyl-2,8 -dioxo-4,5-dihydro-3H-pyrido[4,3-b]azepin-3-yl]-i,2,4-triazole-3-carboxamide (i6.6 mg, 60%) as a white solid.?H NMR (400 MHz, CD3OD) oe 8.57 (s, iH), 7.63 (s, iH), 7.38 – 7.32 (m, 5H), 6.46 (s, iH),5.47 (s, 2H), 4.64 – 4.59 (m, 1H), 3.57 (s, 3H), 3.36 (s, 3H), 2.67 – 2.61 (m, 2H), 2.45 – 2.41(m, 1H), 2.10 – 2.06 (m, 1H). LCMS RT = 0.582 mm, m/z = 407.1 [M + H]. LCMS (5 to95% acetonitrile in water + 0.1% formic acid over 1.5 mins) retention time 0.5 82 mi ESI+found [M+H] = 407.1.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Benzyl-1H-1,2,4-triazole-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; PATEL, Snahel; (105 pag.)WO2018/73193; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics