Application of 27996-86-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27996-86-7, name is 4-[1,2,4]Triazol-1-yl-benzaldehyde belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
A mixture containing 6-iodoquinoline-2,4-diol (1.0 g, 3.5 mmol, Intermediate 4: step b), 4-(1H-1,2,4-triazol-1-yl)benzaldehyde (0.60 g, 3.5 mmol, Intermediate 82: step c), and diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate (0.93 g, 3.5 mmol) in pyridine (17 mL) was heated to 80 C. After 2 hours, the flask was allowed to cool to 23 C. resulting in the formation of a solid. Diethyl ether (20 mL) was added. The solids were collected, washed with diethyl ether, and then dried to provide the title compound as an off-white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-[1,2,4]Triazol-1-yl-benzaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Janssen Pharmaceutica NV; Leonard, Kristi A.; Barbay, Kent; Edwards, James P.; Kreutter, Kevin D.; Kummer, David A.; Maharoof, Umar; Nishimura, Rachel; Urbanski, Maud; Venkatesan, Hariharan; Wang, Aihua; Wolin, Ronald L.; Woods, Craig R.; Fourie, Anne; Xue, Xiaohua; Cummings, Maxwell D.; Jones, William Moore; Goldberg, Steven; US2015/105366; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics