Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23579-79-5, name is 3,5-Dibromo-1-methyl-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C3H3Br2N3
Synthesized according to the method described in WO2011 / 006903A13,5-Dibromo-1-methyl-1 H-1,2,4-triazole (0.5 g)Was dissolved in dioxane (20 ml)And the mixture was stirred at room temperature. To this was added water (3 ml),2-fluoro-4- (trifluoromethyl) phenylboronic acid (0.43 g),Tetrakis (triphenylphosphine) palladium (0) (0.12 g),Cesium carbonate (1.0 g) was added,The inside of the reaction vessel was replaced with nitrogen,The mixture was stirred under heating reflux overnight.The reaction solution was poured into water,And extracted with ethyl acetate.The obtained organic layer was washed with saturated brine,It was dried over anhydrous magnesium sulfate,It was filtered.The filtrate was concentrated under reduced pressure,The obtained residue was purified by silica gel column chromatography to obtain 0.31 g (yield 46%) of the objective compound.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 23579-79-5.
Reference:
Patent; Nippon Soda Co., Ltd.; Aoyama, Hikaru; Banzai, Keita; Iwasa, Takao; Kobayashi, Asami; (43 pag.)JP2017/110003; (2017); A;,
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