Reference of 15294-81-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15294-81-2 as follows.
A mixture of 4,5-dibromo-1,2,3-triazole (1.0 mmol, 227 mg) and Na2SO3 (3.0 mmol, 378 mg) in water (3.0 mL) was stirred at 100 C (hot plate) for 3 days. The mixture was cooled to rt, then extracted with ethyl acetate (5 mL x 2). The combined extract was dried over Na2SO4, filtered, and concentrated in vacuo. The residue was crystallized from ethyl acetate and heptane to give the desired product as a white solid (99 mg, 67% yield). 1H NMR (400 MHz, DMSO-d6) delta 8.10 (s, 1H) ppm. 13C NMR (100 MHz, DMSO-d6) delta 130.6, 120.5 ppm. HRMS calculated for [C2H2BrN3+H]+ 147.9505, found: 147.9502.
According to the analysis of related databases, 15294-81-2, the application of this compound in the production field has become more and more popular.
Reference:
Article; Sakurada, Isao; Tetrahedron Letters; vol. 58; 32; (2017); p. 3188 – 3190;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics