Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.705-86-2, Name is 6-Pentyltetrahydro-2H-pyran-2-one, SMILES is O=C1CCCC(CCCCC)O1, belongs to Triazoles compound. In a document, author is Cordani, Marco, introduce the new discover, SDS of cas: 705-86-2.
Water Soluble Iron-Based Coordination Trimers as Synergistic Adjuvants for Pancreatic Cancer
Pancreatic cancer is a usually fatal disease that needs innovative therapeutic approaches since the current treatments are poorly effective. In this study, based on cell lines, triazole-based coordination trimers made with soluble Fe(II) in an aqueous media were explored for the first time as adjuvant agents for the treatment of this condition. These coordination complexes were effective at relatively high concentrations and led to an increase in reactive oxygen species (ROS) in two pancreatic cancer cell lines, PANC-1 and BXPC-3, and this effect was accompanied by a significant reduction in cell viability in the presence of gemcitabine (GEM). Importantly, the tested compounds enhanced the effect of GEM, an approved drug for pancreatic cancer, through apoptosis induction and downregulation of the mTOR pathway. Although further evaluation in animal-based models of pancreatic cancer is needed, these results open novel avenues for exploring these iron-based materials in biomedicine in general and in pancreatic cancer treatment.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 705-86-2. SDS of cas: 705-86-2.