Some tips on 5-Bromo-1-methyl-1H-1,2,4-triazole

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1-methyl-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Electric Literature of 16681-72-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-72-4, name is 5-Bromo-1-methyl-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

Example 249.; Preparation of 3-[3-chloro-4-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-8-(1-ethyl- propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine.; To a flask of 3-(4-bromo-3-chloro~thiophen-2-yl)-8-(1-ethyl-propyl)-2,6- dimethyl-imidazo[1,2-b]pyridazine (0.20 g, 0.49 mmol) is added 0.5 g/ mL Reike Zn (1.3 mL, 0.97 mmol). The slurry is heated at 65 C for 1 hour, placed in a centrifuge for 5 minutes, and the solution transferred to a flask containing 5-bromo-1-methyl-1H- [1,2,4]triazole (0.12 g, 0.73 mmol) and PdCl2(dppf) (0.018 g, 0.024 mmol). The EPO solution is heated at 65 C overnight, diluted with EtOAc (20 mL), washed with sat. NH4Cl (15 mL), dried over MgSO4, filtered and concentrated. The residue is purified by ISCO flash chromatography (20%-50% EtOAc gradient) furnish the title compound (0.018 g, 0.043 mmol, 9%). 1H NMR (CDCl3) delta 0.87 (t, J = 7.5 Hz, 6H), 1.74-1.92 (m, 4H), 2.51 (s, 3H), 2.52 (s, 3H), 3.26-3.37 (m, 1H), 3.95 (s, 3H), 6.72 (s, 1H), 7.82 (s, 1H), 8.01 (s, 1H). LC/MS (m/z): calcd. for C20H23ClN6S (M+H)+: 415.2; found: 415.3.

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-1-methyl-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/102194; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics