22300-52-3, name is 4,5-Dibromo-2H-1,2,3-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 22300-52-3
Step 1 : Cs2C03 (2.42 g, 7.43 mmol) is added to a stirred solution of A-28.2 (1 .68 g, 7.43 mmol) in dry DMF (10 mL). The mixture is stirred for 10 min before A-28.1 (1.00 g, 4.95 mmol), Cul (56.6 mg, 0.30 mmol) and A-28.3 (63.4 muIota_, 0.45 mmol) are added and the reaction is heated to 1 10¡ãC by microwave irradiation and stirred for 30 min. After cooling, the mixture is concentrated, poured into water and extracted with Et20. The organic phase is dried and concentrated to give the crude product which is purified by flash column chromatography on silica gel (using a solvent gradient from n-hexane/EA = 8/2 to EA 100percent) to provide 1.5 g of A- 28.4. ES+/-: 348 [M+H]+; HPLC (Rt): 0.57 min (Method P).
The synthetic route of 22300-52-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; RIETHER, Doris; FERRARA, Marco; HEINE, Niklas; LESSEL, Uta; NICHOLSON, Janet Rachel; PEKCEC, Anton; (102 pag.)WO2017/178344; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics