6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C8H8N4
To a solution of Intermediate 19 (95mg, 0.29mmol) in acetic acid (ImI) was added A- triazolylaniline (56mg, 0.35mmol) and the solution was stirred at 8O0C over 2 hours. LCMS analysis showed consumption of starting material.Reaction mixture was cooled and the excess acetic acid removed by evaporation under reduced pressure. The residues were treated with sat. aq. Sodium hydrogen carbonate until cessation of effervescence. The resulting precipitate was filtered and the solids obtained dried under vacuum. Purification by preparative chromatography furnished the desired compound as an off- white solid (33mg, 25%)1H NMR (D6-DMSO) 10.24 (IH, bs), 9.27 (IH, s), 8.82 (IH, s), 8.64 (IH, s), 8.36 (IH, s), 8.24 (IH, s), 8.22 (IH, dd, J 9Hz, 1.75Hz), 8.09 (2H, d, J 9Hz), 7.92 (3H, m), 7.64 (IH, dd, J 8.25Hz, 2Hz), 7.46 (IH, m), 4.87 (IH, quin, J 6Hz), 1.36 (6H, d, J 6Hz) LC-MS rt 2.66 m/z 441 ES+
The synthetic route of 6523-49-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics