Reference of 1533519-85-5, These common heterocyclic compound, 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a 1L three-necked flask, add 20.0g of intermediate (4), 80ml of tetrahydrofuran and 20ml of methanol, start stirring, warm up to 40.0C, stir until dissolved; add 20.0g NBS, 0.2g TEMPO, react for 60min; cool to 5C, add ethyl acetate 100ml and purified water 120ml, the organic phase was washed with 120ml of 3% sodium bisulfite solution and 100ml of 5% sodium bicarbonate solution, dried with anhydrous sodium sulfate 50.0g, filtered, rinsed with ethyl acetate 50ml, the mother liquor was concentrated to dryness, 60ml of ethyl acetate was added to the residue, heated until the solid was dissolved, 240ml of n-hexane was added, and the temperature was slowly lowered to 0-5C, filtered, washed, and dried to obtain 22.0g of off-white solid with a yield of 89.4%.
Statistics shows that Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate is playing an increasingly important role. we look forward to future research findings about 1533519-85-5.
Reference:
Patent; Beijing Xinkaiyuan Pharmaceutical Technology Co., Ltd. Hainan Fen Corporation; Xia Zhongning; Wu Jin; Bai Bingxin; (9 pag.)CN111116501; (2020); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics