Related Products of 956317-36-5, These common heterocyclic compound, 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A round-bottom flask equipped with a magnetic stirrer bar was charged with 5-methyl-2-(2H-1,2,3-triazole-2-yl)benzoic acid (5.0 g, 24.6 mmol, 1.0 equiv) and THF (250 mL). Theresulting solution was cooled to 0 C, followed by successive addition of triethyl amine (3.58 mL, 25.8 mmol, 1.05 equiv) and isobutyl chloroformate (3.35 mL, 25.8 mmol,1.05 equiv). The reaction mixture was stirred at ambient temperature for 1 h. Subsequently, the precipitate was filtered off and the filtrate was concentrated under reduced pressure.The residue was taken up in ethyl acetate and washed with saturated NaHCO3 solution. The organic layer was washed with H20, dried over anhydrous sodium sulfate and concentrated under reduced pressure, yielding (isobutyl carbonic) 5-methyl-2-(2H-1,2,3- triazole-2-yl)benzoic anhydride (6.6 g, 88%) as an orange-brown oil.?H NMR (500 MHz, CDC13) oe = 7.80 (s, 2H), 7.70 (d, J = 8.20 Hz, 1H), 7.64 (d, J = 1.45Hz, 1H), 7.45 (dd, J = 1.45, 8.20 Hz, 1H), 3.98 (d, J = 6.60 Hz, 2H), 2.42 (s, 3H), 1.96(sept, J = 6.71 Hz, 1H), 0.91 (d, J = 6.75 Hz, 6H)?3C NMR (125 MHz, CDC13) oe = 161.0, 148.6, 139.0, 136.4, 135.9, 133.8, 131.2, 124.3, 124.1, 75.4, 27.6, 20.9, 18.7
Statistics shows that 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid is playing an increasingly important role. we look forward to future research findings about 956317-36-5.
Reference:
Patent; SANDOZ AG; HOeFERL-PRANTZ, Kathrin; BARTH, Roland; RICHTER, Frank; ZUPANCIC, Borut; (126 pag.)WO2016/20403; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics