According to the analysis of related databases, 4928-88-5, the application of this compound in the production field has become more and more popular.
Related Products of 4928-88-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4928-88-5 as follows.
Example 5; Scheme 7; Benzoic acid 2-acetoxy-5-(diethoxy- 1-[3-Benzoyloxy-5-(diethoxy-phospriorylmethoxy)- phosphorylmethoxy)-tetrahydro-furan-3-yl ester tpsitrahydro-furan-2-yl]-” * * 1H-[1,2,4]triazole-3-carboxylic acid methyl ester261 5 l-[3-Benzoyloxy-5-(diethoxy-phosphorylmethoxy)-tetrahydro-ftiotaran-2-yl]- UEf-[l,2,4]triazole-3-carboxylic acid methyl ester.; Benzoic acid 2-acetoxy-5-(diethoxy-phosphorylmethoxy)-tetrahydro-furcin-3-yl ester (170 mg, 0.4 mmol), lH-tlA^Triazole-S-carboxylic acid methyl ester (5110 mg, 0.4 mmol) and Bis-(p-nitrophenyl)rhohosphate were reacted according to literature procedure (J. Med. Chem. 2000, 43, 1019-1028). The desired product was isolated in 65percent yield (150 mg). 1H NMR (CDCIa, 300 MHz) delta 8.60 (s, IH), 8.00 (d, 2H, / = 7.8 Hz), 7.60 (t, IH, /= 7.2 Hz), 7.45 (app t, 2H, / = 7.7 Hz), 6.29 (d, IH, /= 1.5 Hz), 5.91-5.98 (m, IH), 5.67-5.71 (m, IH), 4.11-4.23 (m, 4H), 3.96-4.0415 (m, 4H), 3.85-3.92 (m, IH), 2.55-2.72 (m, 2H), 1.29-1.37 (m, 6H). 31P NMR (121.4 MHz, CDCl3) delta 19.8. LRMS (ESI) MH+ C20H27N3O9P requires 484.1 Found 483.8.
According to the analysis of related databases, 4928-88-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GILEAD SCIENCES, INC.,; WO2008/5542; (2008); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics