Some common heterocyclic compound, 103755-58-4, name is (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol, molecular formula is C9H9N3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: (1-Phenyl-1H-1,2,3-triazol-4-yl)methanol
General procedure: The 1-substituted-1,2,3-triazol-4-yl-methanol 1 (4mmol) was taken in dry acetone (10mL), cooled to 0C and the Jones reagent (CrO3+H2SO4+Acetone) (4mmol) was added slowly over a period of 15min. The reaction mixture was stirred for 20min at 0C. After completion of reaction, filtered through the short pad of celite and the filtrate was collected and concentrated under vacuum. The residue was purified by passing through a column packed with silica gel using petroleum ether/EtOAc (8:2) as eluents.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 103755-58-4, its application will become more common.
Reference:
Article; Sambasiva Rao; Kurumurthy; Veeraswamy; Santhosh Kumar; Poornachandra; Ganesh Kumar; Vasamsetti, Sathish Babu; Kotamraju, Srigiridhar; Narsaiah; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 184 – 191;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics