Synthetic Route of 7411-23-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.
Intermediate 5 3,5-dibromo-l-(2-methylpropyl)-lH-l,2,4-triazole Sodium te/t-butoxide (699 mg, 7.27 mmol) was added to a solution of 3,5-dibromo-l/-/-l,2,4- triazole (1.5 g, 6.61 mmol) in DMF (10 mL). The mixture was stirred at rt for 10 minutes. 1- Bromo-2-methylpropane (0.8 mL, 7.27 mmol) was added and the mixture was heated at 50C for 4 h and let to rt. Water (100 mL) was added and the mixture was extracted with EtOAc (2 x 50 mL). The organic phase was washed with brine (50 mL) and dried over sodium sulfate and concentrated to give the title compound as a liquid (1.47 g, 79%). XH NMR (400 MHz, CDCI3): delta ppm 0.94 (d, 6 H), 2.21 – 2.32 (m, 1 H), 3.93 (d, 2 H).
The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ACTURUM LIFE SCIENCE AB; BESIDSKI, Yevgeni; YNGVE, Ulrika; PAULSEN, Kim; LINDE, Christian; MALMBORG, Jonas; WO2014/195322; (2014); A1;,
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