Application of 7343-33-1,Some common heterocyclic compound, 7343-33-1, name is 5-Bromo-1H-1,2,4-triazole, molecular formula is C2H2BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2- [6-Chloro-3- (ethanesulfonyl) pyridin-2-yl] -3-methyl-6 – [(trifluoromethyl) sulfanyl]-3H-imidazo [4,5-b] pyridine 200 mg, 60percent sodium hydride (oily) 54 mg, and a mixture of 1 ml DMF, was added 3-bromo-1H-1,2,4-triazole 198mg under ice-cooling. After the mixture was stirred under ice-cooling for 2.5 hours, a saturated aqueous solution layer was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with water, and saturated brine, and dried with anhydrous sodium sulfate. The resulting organic layer was dried under reduced pressure. The resulting residue was subjected to silica gel chromatography to obtain 83mg of the present invention of compounds beta39 that described below.
The synthetic route of 7343-33-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; NAKAJIMA, YUJI; OKAWARA, YUICHI; (263 pag.)JP2016/102104; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics