These common heterocyclic compound, 81606-79-3, name is 2-(1,2,4-Triazol-1-yl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 2-(1,2,4-Triazol-1-yl)acetonitrile
To a solution of [1,2,4] Triazol-1-yl-acetonitrile (1.5 grams, 13.9 mmol) in ethanol were added sodium carbonate (4.4 grams, 41.7 mmol) and hydroxylamine hydrochloride (3.86 grams, 55.5 mmol). The mixture was heated to 80 0C for overnight. The reaction mixture was concentrated and extracted with ethyl acetate and purified by column to get the desired product (1.9 grams).Yield: 97%1H NMR (200 MHz, CDC13+DMSO): delta 9.34 (bs, IH), 8.51 (s, IH), 7.95 (s, IH), 5.58 (bs, 2H),4.74 (s, 2H).ES-MS (m/z): 142 (M++1)
The synthetic route of 2-(1,2,4-Triazol-1-yl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DR. REDDY’S LABORATORIES LIMITED; DR. REDDY’S LABORATORIES, INC.; WO2008/143649; (2008); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics