Related Products of 118863-62-0, A common heterocyclic compound, 118863-62-0, name is 3-(4-Bromophenyl)-1H-[1,2,4]triazole, molecular formula is C8H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 221 (S)-1-(1-(4-(1H-1,2,4-Triazol-3-yl)phenyl)-8,9-dihydro-7H-6-oxa-2,9a-diazabenzo[cd]azulen-4-yl)pyrrolidine-2-carboxamide 221 221 was prepared using commercially available 3-(4-bromophenyl)-1H-1,2,4-triazole and following procedures analogous to those of Example 158. LCMS: RT (min)=3.00, [M+H]+=430, method=C; 1H NMR (300 MHz, DMSO-d6) delta 14.22 (s, 1H), 8.68 (s, 1H), 8.17 (d, J=8.1 Hz, 2H), 7.90 (d, J=7.8 Hz, 2H), 7.31 (d, J=2.3 Hz, 1H), 7.03 (s, 1H), 6.37 (d, J=2.1 Hz, 1H), 6.09 (d, J=2.1 Hz, 1H), 4.37-4.29 (m, 4H), 3.90-3.80 (m, 1H), 3.70-3.60 (m, 1H), 3.30-3.08 (m, 1H), 2.35-2.15 (m, 3H), 2.09-1.87 (m, 3H).
The synthetic route of 118863-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics