Adding a certain compound to certain chemical reactions, such as: 202931-88-2, name is 1-Methyl-1H-1,2,3-triazole-5-carbaldehyde, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202931-88-2, Recommanded Product: 202931-88-2
6-bromo-4-chloro-2-methoxy-3 – (4 – (trifluoromethyl) benzyl) quinoline (1.45 g, 3.37 mmol, Intermediate 10: step d) comprises that the flask, THF (25 was added to mL), the solution was cooled to -75 .n-BuLi (dropwise 2.5 M, 1.3 mL, 3.25 mmol )in hexane.After 2 minutes, 3 mL of THF 1 -methyl -1H-1,2,3-triazole-5-carbaldehyde (580 mg, 5.22 mmol, Intermediate 18) was introduced.The reaction mixture was warmed to -20 over 45 minutes and, at this time the reaction NH4was quenched with aqueous solution of Cl.Extract the aqueous portion with EtOAc (5 × 40 mL), washing the combined organics with brine, MgSO4dried over, filtered and concentrated.Silica gel (5% CH3CN-DCM, 30% CH3by chromatography on increased to CN + 2% MeOH), to give the title compound as a pale yellow non-crystalline solid.
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Reference:
Patent; Janssen Pharmaceuticals N.V; Leonardo, Christi.A.; Barvei, Kent; Edward, James P.; Gloita, Kevin D.; Kummer, David .A.; Maharoof, Umar; Nishimura, Rachael; Urbanski, Mode; Venkatesan, Hariharan; Wang, Ai Hua; Olin, Ronald L.; Woods, Craig; Fourier, Anne; Shu, Jih; Cumings, Maxwell D.; (86 pag.)KR2016/68948; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics