Reference of 4320-91-6, New Advances in Chemical Research in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic,A common heterocyclic compound, 4320-91-6, name is 2H-1,2,3-Triazole-2-acetic acid, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Preparation 20: N-(4-Chlorophenyl)-2-(2H-1,2,3-triazol-2-yl)acetamide. A mixture of the product of preparation 19 (5.2 g, 41 mmol), 4-chIoroaniline (5.2 g, 41 mmol), 4- methylmorpholine (12.4 g, 123 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (8.65 g, 45 mmol) and 1-hydroxybenzotriazole hydrate (6.08 g, 45 mmol) in dichloromethane (200 ml) was stirred at room temperature for 18 hours. It was then diluted with dichloromethane (150 ml) and washed with brine (2 x 100 ml). The organic layer was concentrated in vacuo affording a brown solid. This solid was washed with isopropyl alcohol (50 ml) to afford a first crop of title compound as a white solid. The aqueous brine washing was then re-extracted with dichloromethane (2 x 100 ml) and the organic solution was concentrated in vacuo to afford further title compound, providing a total of yield 65%, 6.25 g. 1HNMR(400MHz, CDCI3) delta: 5.24(s, 2H), 7.22(d, 2H), 7.40(d, 2H), 7.78(s, 2H) 8.05(bs, 1H); LRMS APCI m/z 259 [M+Na]+.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 2H-1,2,3-Triazole-2-acetic acid, hurry up and to see.
Reference:
Patent; PFIZER LIMITED; WO2006/123242; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics