Application of 184177-83-1, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 184177-83-1, name is 1-((2S,3S)-2-(Benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 8a was added to a mixture of KOH (33%) solution and DMSO and stirred at room temperature for 45 min; the compound4a was added to the above reaction system, and the reaction was stirred at 50 ± 5 C for 5 h. The reaction mixture was extracted with 40 mL of water and extracted with ethyl acetate. The aqueous phase was extracted with ethyl acetate. The organic phases were combined, washed with brine and dried to give a solid product. The product was recrystallized from ethanol and filtered to give white solid 7a, Yield 85%, HPLC purity 96%.
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Reference:
Patent; Gansu Haotian Chemical Technology Co., Ltd.; Feng Weiwei; Zhang Hongrui; Wang Shixiang; Wang Shijiao; Wei Pengfei; Da Shijun; (17 pag.)CN106632284; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics