Electric Literature of 89292-91-1, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 89292-91-1, name is 5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine, molecular formula is C7H14N6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
General procedure: A solution of aminotriazole 11a-m (3.1mmol), glacial acetic acid (5mL), and diethyl ethoxymethylenemalonate (4.6mmol) was refluxed for 3h. After cooling to room temperature, the resulting precipitate was collected by filtration, washed with cold water and dried. The residue was stirred with cold ethyl ether (20mL) and filtered to afford the desired product. Following general procedure C, compound 12k was isolated as a white solid. Yield 78%, mp=220C dec. 1H NMR (200MHz, DMSO-d6) delta: 9.95 (br s, 1H); 8.41 (s, 1H); 4.17-4.07 (q, J=7Hz, 2H); 3.78-3.45 (m, 4H); 2.76 (s, 3H); 2.52-2.49 (m, 4H); 1.26-1.19 (t, J=7.2Hz, 3H)
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 5-(4-Methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine, hurry up and to see.
Reference:
Article; Aghazadeh Tabrizi, Mojgan; Baraldi, Pier Giovanni; Ruggiero, Emanuela; Saponaro, Giulia; Baraldi, Stefania; Poli, Giulio; Tuccinardi, Tiziano; Ravani, Annalisa; Vincenzi, Fabrizio; Borea, Pier Andrea; Varani, Katia; European Journal of Medicinal Chemistry; vol. 113; (2016); p. 11 – 27;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics