Synthetic Route of 7411-23-6, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Weigh the raw material 3,5-dibromo-1,2,4-triazole in 50mL of dichloromethane solution.After slowly adding the tungyl acid chloride at a molar ratio of 1: 2, the reaction was started under reflux at 0 C for 2 hours.Follow-up detection by thin-layer chromatography. After the reaction is completed, an appropriate amount of water is added and washed 3 times.Dichloromethane was added and shaken for extraction. The lower layer of the liquid was removed under reduced pressure to remove the solvent, and dried over anhydrous sodium sulfate.The obtained crude product was added with absolute ethanol at a ratio of 1: 1 g / mL, and recrystallized at -20 C.After filtration, the solvent was evaporated to obtain the corresponding compound 2,
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Reference:
Patent; China Institute Of Forestry Forest Products Chemical Industry Institute; Huang Lixin; Cheng Jiang; Zhang Caihong; (6 pag.)CN110835322; (2020); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics