Synthetic Route of 13423-60-4, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 13423-60-4, name is 1-Phenyl-1H-1,2,4-triazole, molecular formula is C8H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
General procedure: Solutions of 3.0 mmol of 3-methylindole (for the synthesis of 10a-d) and 4.0 mmol of 3-methylpyrrolo[2,3-b]pyridine (for thesynthesis of 19a-d), respectively, in 10 mL of dioxane or acetonewere treated under an inert atmosphere with 5.3 mmol (10a-d) or4.0 mmol (19a-d) of the imidazoles 9aed, or 5.3 mmol of 1-phenyl-1,2,4-triazole (23). Then the solutions were cooled to12-15 C and 4.4 mmol of N-bromosuccinimide (NBS) was added portionwise within 5 min. After stirring over a period of 30 min theimidazolium salts were filtered off (10aed) or precipitated by additionof a mixture of ethanol and diethyl ether (19a-d). The products were obtained as colorless to slightly yellow solids.
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Reference:
Article; Pidlypnyi, Nazar; Wolf, Sebastian; Liu, Ming; Rissanen, Kari; Nieger, Martin; Schmidt, Andreas; Tetrahedron; vol. 70; 45; (2014); p. 8672 – 8680;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics