New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 288-88-0, name is 1H-1,2,4-Triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 1H-1,2,4-Triazole
EXAMPLE 1 This Example illustrates the preparation of 1-trityl-1,2,4-triazole. A solution of trityl chloride (417.7 g) in dichloromethane (1.21) was added slowly over two hours, whilst maintaining the temperature below 50 C. by external cooling, to a solution of 1,2,4-triazole (103.5 g) and triethylamine (151.5 g, 209 ml) in N,N-dimethylformamide (500 ml). The mixture was then stirred for a further one hour, poured into water (21) and extracted with dichloromethane (5*500 ml). The extracts were dried over magnesium sulphate, evaporated under reduced pressure and the crude product triturated with ether (200 ml total) to give the title compound (425 g, m.p. 213-214 C.). NMR (CDCl3): delta7.1-7.4 (15H,m), 8.03(1H,s), 8.08(1H,s).
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Reference:
Patent; Zeneca Limited; US5393732; (1995); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics