Related Products of 6523-49-5, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, molecular formula is C8H8N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
a 2-[5-(1,2,4-Triazol-1-yl)-1H-indol-3-yl]ethyl alcohol Prepared from 4-(1,2,4-triazol-1-yl)aniline (EP497512) as described for Intermediate 3, delta (250 MHz, D6 -DMSO) 2.89 (2H, t, J=7.2 Hz, CH2), 3.64-3.74 (2H, m, CH2), 4.67 (1H, t, J=5.3 Hz, OH), 7.29 (1H, d, J=2.3 Hz, Ar–H), 7.47 (1H, dd, J=8.7 and 1.5 Hz, Ar–H), 7.53 (1H, dd, J=8.7 and 2.3 Hz, Ar–H), 7.95 (1H, d, J=1.9 Hz, Ar–H), 8.19 (1H, s, Ar–H), 9.19 (1H, s, Ar–H), 11.10 (1H, s, NH).
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 4-(1,2,4-Triazol-1-yl)aniline.
Reference:
Patent; Merck Sharp & Dohme, Ltd.; US5854268; (1998); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics