Related Products of 6523-49-5, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Formamidine from step 1(2.96 g, 9.6 mmol) and 4-triazolylaniline (1.54 g, 9.6 mmol) in AcOH (10 ml) were heated to reflux for 3 h. The cooled solution was diluted with ether (200 ml) and the resulting precipitate filtered off. The filter cake was washed with ether, dried under suction then slurried with 2N NaOH (100 ml) with stirring for 30 minutes. The resulting solid was again isolated by filtration, washed with water and dried to give a pale yellow solid (3.81 g, 93 %). 1H NMR deltaltheta.11 (IH, s), 9.30 (IH, s), 8.80 (IH, s), 8.65 (IH, s), 8.26 (IH, s),8.23 (IH, s), 8.10 (2H, d, J 10Hz)5 7.92 (2H5 d, J 10Hz ), 7.88 (IH, d, J7.5Hz), 7.47 (2H, overlapping s), 7.16 (IH, d, J7.5Hz), 3.93 (3H, s), 3.85 (3H, s); LC-MS rt 2.17 m/z 425 ES+.
This is the end of this tutorial post, and I hope it has helped your research about 6523-49-5!
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics