Related Products of 342617-08-7, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 342617-08-7, name is 3-(3-Bromophenyl)-4H-1,2,4-triazole, molecular formula is C8H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
B. 3-(3-(TrimethylstannyI)phenyl)-lH-l,2,4-triazole. A solution of 3-(3- bromophenyl)-lH-l,2,4-triazole (0.5 g, 2.25 mmol) in dry toluene (20 mL) was treated with hexamethylditin (0.88 g, 2.70 mmol) and tetrakis(triphenylphosphine)palladium(0) (255 mg, 0.22 mmol) in a sealed tube at 110 C for 2.5 h. The volatiles were removed under reduced pressure and the crude product was purified by biotage (0-50% ethyl acetate in hexanes) to afford the desired stannane (200 mg, 29%). MS (ESI) m/z 310.3[M+l]+.
We very much hope you enjoy reading the articles and that you will join us to present your own research about 342617-08-7, Happy reading!
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2008/51493; (2008); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics