New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Product Details of 1001401-62-2
A solution of 2-(2H-1,2,3-triazol-2-yl)benzoic acid (4.3 g, 0.023 mol) in 15 mL of 50C12 was heated at 50 C for 30 mins. After cooling to RT, the mixture was concentrated in vacuo to remove the solvent. To a solution of the product from step 1 (3.3 g, 0.02 mol) and TEA (8.7 mL, 0.06 mol) in dry DCM (10 mL) at 0 C was added a solution of the above residue inDCM (10 mL) dropwise. The resulting mixture was stirred at RT overnight. The mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (50% EtOAc in petroleum ether) to give the title compound as an oil. LRMS m/z (M+H) 331.1 found, 331.2 required.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (58 pag.)WO2016/89722; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics